![]() The study included 1661 patients and the main study population was the 1347 with melanoma of Breslow thickness between 1.2 and 3.5 mm. Patients in the observation arm underwent therapeutic lymph node dissection (tLND) if they developed clinical lymph node involvement. This was a phase III randomised controlled trial comparing wide excision of the primary melanoma and regional nodal observation with wide excision and SLNB followed by immediate completion lymph node dissection (cLND) for patients with a positive SLNB. The most important of these publications is the final report of the Multicentre Selective Lymphadenectomy Trial (MSLT-I). There have been numerous large studies published since the last guidelines regarding the role of SLNB in melanoma. SLNs are carefully examined pathologically to identify metastasis.īack to top Summary of systematic review results This dual modality approach allows the successful identification of a SLN in over 95% of patients. A node is considered a SLN if it has tracer uptake and/or is stained blue. Intraoperative exploration through a small incision allows the identification of SLNs. This is followed by intraoperative intradermal injection of the melanoma site with patent blue dye. Briefly, it involves pre-operative lymphoscintigraphy to identify the draining nodal basin for the anatomical location of the primary melanoma. The technique of SLNB has been extensively described. The recently revised AJCC staging system (8th edition) requires a SLNB for patients with primary melanoma greater than 1mm in thickness in order to perform microstaging of the lymph node basin and accurately allocate a pathological disease stage. Numerous studies have consistently demonstrated that the status of the sentinel lymph node (SLN) reflects the status of the entire draining nodal basin as measured by elective lymph node dissection. The technique was developed as a staging procedure to identify patients with a positive draining nodal basin and thereby minimise the morbidity associated with elective lymph node dissection in patients who may not require this procedure. Sentinel lymph node biopsy (SLNB) is a surgical technique to identify low volume metastatic disease within the draining lymph node basin in patients undergoing treatment for primary melanoma.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |